As a result of the Genome Project, which finds the various genetic information possessed by humans and plants and animals, a variety of genomic information including all gene sequences (DNA, mRNA, nsRNA, miRNA...) before protein generation is generated In order to study various life phenomena (differentiation, development, metabolism, drug response, disease mechanisms, etc.) occurring in living things, there is a limit to research at the individual gene level. this came to be Cells, the most basic unit of life, have very large computing power that can independently perceive. Cells gather according to a set time schedule to form tissues, organs, systems, and entities in stages, and various life phenomena must occur precisely, automatically and appropriately. can do. DNA sequence information contains not only sequence information of coding/non-coding genes, but also information on epigenetic modifications, interactions between each protein & DNA, and rapidly changing Nucleoprotein Complex.

In the past, proteins in cells were studied one at a time, but with the development of innovative technology, it is now possible to study all proteins in cells at once. More specifically, identification of proteins to find out which proteins are expressed in cells, quantification to determine how the amount of each protein changes in the disease state compared to the normal state, and protein function It refers to the analysis of three-dimensional structures, which is essential for determining, post-translational modification analysis that studies the modification of proteins in cells after protein expression, and analysis of protein-protein interactions.

In particular, it is the development of mass spectrometry technology that has provided a breakthrough in proteomic analysis, and is currently being used extensively in all stages of analysis, such as proteomic identification, quantification, structure, interaction, and PTM. In particular, mass spectrometry is the only technology capable of rapidly performing PTM analysis in large quantities. However, since various databases and software must be used to interpret the mass spectrometry results, an in-depth understanding of these is essential for research. In addition, as the data production speed increases in recent proteomic research, the use of computing technology for processing large amounts of data is also becoming an important issue.

Systems biology is a field of study that seeks to understand life phenomena within complex systems. Previous studies in the field of general biology have focused on one or two molecules of interest using a simplified model system. As a result, it is true that there were many theories and methods that worked well in vitro, but did not apply to the living body. This is a problem caused by trying to understand living things too simply, while ignoring complex systems. In order for a person to live, he has to have relationships with many other people around him. Because there is that person in the midst of living with many people, such as family, friends, co-workers, etc., ignoring all these relationships and analyzing only one person may make it impossible to understand or misunderstand the person itself. The approach to life is the same. One protein is said to be correlated with at least six other proteins. Therefore, in order to accurately understand the function of a specific protein or gene in vivo, it is necessary to analyze the system as it is, instead of reducing and simplifying the system. That is the direction systems biology is ursuing.